Safety of antimalarial drugs exposure during early pregnancy

The safety of antimalarial drugs in pregnancy.

Alternative drugs to chloroquine are required to prevent the deleterious effects of malaria in pregnancy. Fear of potential toxicity has limited antimalarial drug use in pregnancy. Animal toxicity studies have documented teratogenicity when antimalarials are administered at high dosages. Excepting the tetracyclines, there is no evidence to suggest that, at standard dosages, any of the antimalar...

Antimalarial drugs and pregnancy: safety, pharmacokinetics, and pharmacovigilance.

Before a recommendation for antimalarial drug use in pregnancy is made, it is essential that we understand the potential risks involved and have mechanisms in place to monitor risk during treatment. This requires data on drug disposition during pregnancy and potential toxicological liabilities to the developing fetus and mother. In most cases this information is not available. We review the rep...

Comparative safety of antiepileptic drugs during pregnancy.

OBJECTIVE To assess the safety of the newer antiepileptic drugs (AEDs) during pregnancy. METHODS The study population was pregnant women who enrolled in the North American AED Pregnancy Registry between 1997 and 2011. Data on AED use and maternal characteristics were collected through phone interviews at enrollment, at 7 months' gestation, and postpartum. Malformations were confirmed by medic...

Pregnancy Exposure Registries for Assessing Antimalarial Drug Safety in Pregnancy in Malaria-Endemic Countries

1310 September 2008 | Volume 5 | Issue 9 | e187 Because pregnant women are routinely excluded from prelicensure clinical trials for fear of harming the mother or the developing foetus [1], most drugs are marketed with limited information on their safety during pregnancy and therefore are not recommended for use by pregnant women. Yet drugs are widely used by pregnant women, and medication often...

Effectiveness of antimalarial drugs.